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New Method for Splitting Proteins Could Lead to Safer and More Effective Bioengineered Systems

Proteins are the workhorses that run all biological systems. Controlling when and how a protein performs its function provides bioengineers with exquisite control to manipulate or monitor a biological system. In this paper, researchers at Northwestern and the University of Wisconsin–Madison demonstrate a powerful design strategy for splitting bioactive proteins into fragments that only recombine under specific conditions.